Lab-on-a-Chip Technologies for Point-of-Care Diagnostics
Date(s) - 10/22/2019
5:30 pm - 7:30 pm
Categories No Categories
5:30 – Registration and Refreshments
6:00 – Presentation
6:45 – Q&A
Recent infectious disease outbreaks, such as Ebola, highlight the need for fast and accurate diagnostic tools to combat the global spread of the disease. Worldwide, infectious diseases cause 16% of deaths each year. To combat such diseases, improvements in diagnostic technologies to enable rapid and accurate detection of bacteria/viruses are needed. Conventional systems are still time-consuming and are not suitable for point-of-care applications. Lab-on-a-chip technologies have shown a promise for early diagnosis of disease conditions at the point-of-care. In a ‘lab-on-a-chip’ device several laboratory functions are shrunk into a single ship, typically about the size of a credit card.
This presentation summarizes the development of lab-on-a-chip devices for biotechnology applications utilizing highly sensitive thermoelectric sensors and nucleic acid detection for point-of-care applications. A focus on the research work related to
i) Design, fabrication, and optimization of highly sensitive thermoelectric sensors and their applications to biotechnology,
ii) Spatial gradient microfluidic thermal reactors for nucleic-acid sensing, and
iii) Portable nucleic acid diagnostics powered by sunlight, flame or electricity for resource-limited settings.
Varun Kopparthy, PhD
Research Associate, Cleveland Clinic
Dr. Varun Kopparthy is a research associate in the Department of Plastic Surgery at Cleveland Clinic. His current research focuses on the design and development of the ex vivo normothermic perfusion system for the preservation of amputated human extremities. Prior to this, Dr. Kopparthy was a postdoctoral researcher at Cornell University, where he developed a point-of-care nucleic acid diagnostic tool for Kaposi’s sarcoma detection in limited-resource settings. He was the founder and CEO of BioSense Labs, a biotechnology company focused on the development of point-of-care pathogen detection in food and other consumables. Dr. Kopparthy also worked as a Research and Development Engineer at Biovations, LLC, where he has developed a benchtop genetic mutation detection system based on thermal sensing platform technology. Dr. Kopparthy earned his MS and Ph.D. degrees in biomedical engineering at Louisiana Tech University and his bachelor’s degree in biomedical engineering at Jawaharlal Nehru Technological University, India. His thesis research was in the field of lab-on-a-chip nucleic acid analysis for point-of-care diagnostics. He was awarded the CBERS Ph.D. Candidate Outstanding Research Award for his contributions to biomedical research at Louisiana Tech University and several local and state entrepreneurial awards and fellowships.
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